Stratifying high-risk patients with unstable angina (UA) still represents a clinical and therapeutical challenge. Aim: To determine independent clinical and angiographic predictors of poor long-term outcome in patients with UA. Method: A combined cardiac death and non-fetal myocardial infarction (NFMI) as well as combined cardiac death, NFMI an recurrent UA during follow-up (3913 months) was monitored in 94 consecutive patients (61 males, aged 568.7 years) with confirmed UA admitted to the CCU. The Cox univariate and multivariate survival analyses were used to determine independent predictors. Results: Cox univariate analysis revealed 6 predictors among many clinic and angiographic variables: number of vessels diseased, diabetes, previous MI, UA score, admission heart rate, 2mm or higher ST depression in precordial leads. Predictors of combined death and NFMI by Cox multivarlate analysis were: number of vessels diseased, previous MI and 2mm or higher ST depression in precordial leads. The only predictor of combined death, NFMI and recurrent UA by multivariate analysis was number of vessels diseased. Conclusion: The number of vessels diseased is the strongest predictor of poor long-term outcome in our patients with UA.

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