We investigated effectiveness of the determination C-reactive protein (CRP) as early marker for cardiovascular disease. Quantitative determination the CRP is based on a immunaturbidimetry technique on the Dade Behring Dimension RxL clinical chemistry system. We have determined CRP values in 127 patients. Elevated levels of CRP (>5 mg/L) were found in 43% patients with increased concentracion of total cholesterol, tryglicerides and apolipoprotein B and decreased concentracion of HDL-cholesterol and apolipoprotein A. In 20 patients with myocardial infarction and increased CK-MB activities were found levels of CRP about 5-6 times the upper reference limit. Results shown that CPK may be early marker for cardiovascular disease. High - sensitivity methods for CRP (RCRP) measurement are needed for this purpose.