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| EARLY
REPAIR AS A MODERN STRATEGY IN CONGENITAL HEART DEFECTS: WHY
AND WHEN? |
|
G. Wollenek |
| Department
of Cardiothoracic Surgery, University and General Hospital
Vienna, Vienna, Austria |
In pediatric
cardiac surgery there is a general trend towards early repair,
thus avoiding palliative procedures and long-term sequelae, e.g.
in tetralogy of Fallot, ventricular and atrioventricular septal
defect. In some other malformations, the physiology requires very
early intervention, e.g. in transposition of the great arteries
an arterial switch procedure should be performed within the first
two weeks of live. Our experiences with these groups of patients
(120 arterial switch procedures, all neonates, 80 AVSD, 450 isolated
ventricular septal defects and 400 tetralogy of Fallot, 10 % of
them infants) are analyzed with regard to indications and contraindications,
as well as results, thereby comparing the age group of neonates
and infants with other age groups. Mortality rates for infants
are significantly lower than compared with the historical group
of patients, and reasonable compared with a mortality rate of
0 % in children older than one year. Contraindications include
i.e. complex anatomy, severely hypoplastic pulmonaries, and the
need for conduits. Age and weight are no contraindication: at
repair the younges patients were newborn, the minimum weight 1.800
g for VSD and TGA, 3.000 g for Fallot and AVSD. So in congenital
heart defects, even in the asymptomatic child, there has to be
strived for early repair, regardless of off age and weight, but
with cautious individual risk evaluation. This trend may continue:
nowadays the prenatal echocardiography reveals cardiac malformations
in a very early state, As a consequence, fetal cardiac surgery
could be developed as an therapeutic alternative for unborn developing
hypolastic left heart syndrome. In a series of animal experiment
we have proven the technical feasibility. Still further studies
and significant improvements in technical details and safety margins
are required before a realization in human medicine could be taken
into consideration. But as least as important are the ethical,
religious and socio-economical questions with this development.
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