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METABOLIZAM > minerali i vitamini > antioskidansi

Preporučene doze iz literature za suplementaciju antioskidansima kod teško oboljelih pacijenata. (Vrijedi za jedinice intenzivne njege)

na dan Galban Rodriguez
2000
Berger&Shenkin
(2000)
Borhani&Helton
2000
Vit A 3,3 mg (najbolje B-karoten) 1-2 mg
Vit E 364- 910 mg 150 - 200 mg 910 mg
Vit C 2000 250 - >1000 > 1000 mg
Selenijum 100 mikrograma 100- 500 mg  
Cink 50 mg 10 - 40 mg  

U kliničkim studijama, izuzetno teško oboljelim pacijentima, su davani sljedeći nivoi antioksidanasa:

  enteralno/oralno parenteralno
B-karoten (mg) 0,5- 30   
Vit E (mg) 1,2 - 1456 12 -400 mg
Vit C (mg) 96 - 1127 1000 - 3000
Selenijum (mg) 500 - 600 mikrograma 59 - 1000 mg
Cink (mg)    13 - 30 mg

Najviši tolerirani nivo unosa za antioksidanse. Prema :
Food and Nutrition Board, Američkog instiuta za medicinu, US 2000, 2002
.

Životna dob godine Vit E
(mg)
Vit C
(mg)
Selenijum
(mg)
Cink
(mg)
B -karotenoidi
(mg)
UL
9-13
600 1200 280 23 bez podataka
14-18 800 1800 400 34 bez podataka
>18 1000 2000 400 40 bez podataka
odrasli
(NOAEL)
250 mg/kg t.t. 2000 800 40 bez podataka

UL (upper intake levels) - tolerirani gornji nivo unosa, maksimalna količina nutritiva koja nema štetnih osljedica. Baziran je na osnovu:
NOAEL (no observed adverse effect level) - podaci o najvišem nivou unosa za koji nije zabilježen popratni neželjeni efekat kod ljudi
.

  dr. Merim Omerhodžić

Literatura:

  • Baines M, Lack of effectiveness of short-term intravenous micronutrient nutrition in restoring plasma antioxidant status after surgery. Clin Nutr, 2002 Apr; Vol. 21 (2), pp. 145-50;
  • Berger MM, Copper, selenium, zinc, and thiamine balances during continuous venovenous hemodiafiltration in critically ill patients. Am J Clin Nutr, 2004 Aug; Vol. 80 (2), pp. 410-6;
  • Berger MM, Influence of selenium supplements on the post-traumatic alterations of the thyroid axis: a placebo-controlled trial. Intensive Care Med, 2001 Jan; Vol. 27 (1), pp. 91-100;
  • Berger MM, Trace elements in trauma and burns. Curr Opin Clin Nutr Metab Care, 1998 Nov; Vol. 1 (6), pp. 513-7;
  • Berger MM, Trace element supplementation modulates pulmonary infection rates after major burns: a double-blind, placebo-controlled trial., Am J Clin Nutr, 1998 Aug; Vol. 68 (2), pp. 365-71;
  • Borhani NO Exposure to trace elements and cardiovascular disease., Circulation, 1981 Jan; Vol. 63 (1), pp. 260A-263A;
  • Bulger EM, Nutrient antioxidants in gastrointestinal diseases., Gastroenterol Clin North Am, 1998 Jun; Vol. 27 (2), pp. 403-19;
  • Galbán Rodríguez CJ; Early enteral nutrition and immunonutrition] Nutrición enteral precoz e inmunonutrición, Nutr Hosp, 2000; Vol. 15 Suppl 1, pp. 75-85;
  • Gidden F, Clinical micronutrition. Nurs Times, 1997 Jun 18-24; Vol. 93 (25), pp. suppl 1-6;
  • Helton WS, Nutritional issues in hepatobiliary surgery., Liver Dis, 1994 May; Vol. 14 (2), pp. 140-57;
  • Manning EM, Nutritional assessment in the critically ill., Crit Care Clin, 1995 Jul; Vol. 11 (3), pp. 603-34;
  • Mishra V, Markers of oxidative damage, antioxidant status and clinical outcome in critically ill patients., Ann Clin Biochem, 2005 Jul; Vol. 42 (Pt 4), pp. 269-76;
  • Shenkin A, Micronutrients in the severely-injured patient. Proc Nutr Soc, 2000 Aug; Vol. 59 (3), pp. 451-6;
  • Shenkin A, Micronutrients and outcome., Nutrition, 1997 Sep; Vol. 13 (9), pp. 825-8;
  • Shenkin A, Trace elements and inflammatory response: implications for nutritional support., Nutrition, 1995 Jan-Feb; Vol. 11 (1 Suppl), pp. 100-5;
  • The A.S.P.E.N. 2000 Research Workshop: Nutrition Support in Transplantation. (eng) By Helton WS, JPEN J Parenter Enteral Nutr, 2001 May-Jun; Vol. 25 (3), pp. 111-3

Reklamne poruke





F r e s e n i u s

K a b i
 
Normalan metabolizam
Katabolizam
Pedijatrija 1-12 god.
Diabetes mellitus
Hepatična insuficijencija
Renalna insuficijencija
Kritična oboljenja
Onkologija
Malapsorpcija
Povećane energetske potrebe
Disfagija

Oksidacija piruvata i Acetil-CoA

Krebsov ciklus, ciklus limunkse kiseline

Sir Hans Adolf Krebs

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